June 2025
Contributors:
Jean-François Gestin, Molly McGaughan, Kostja Paschalidis, Estelle Ricoux
An overview of isotope types, ligands, targets, companies in the space, manufacturing methods, global demand, and current access.
Our Radionuclide Ecosystem Overview offers a comprehensive examination of the rapidly evolving landscape of radionuclide therapies and the ecosystem that supports it. We designed this resource to help industry leaders, innovators, and investors understand the complexities and interdependencies that define this growing field.
The current state of the radionuclide therapy industry
The spectrum of therapeutic and diagnostic isotopes in development or in use
The diversity of ligands and biological targets being explored and deployed
Key players shaping the radionuclide industry
The infrastructure and processes required to produce radionuclide therapies at scale
Market access dynamics and delivery challenges across geographies
There's more to explore. We'll be adding new content regularly, including deep dives into regulations and market access.
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As competition intensifies, simplifying and aligning complex systems into dependable services is essential to meet growing patient demand.
To scale Radioligand Therapy (RLT), pharmaceutical companies must evolve into full-service providers capable of managing the unique operational demands that come with personalized, made-to-order treatments.
This requires building new capabilities, establishing new roles, and putting in place the processes needed to sustain a connected service infrastructure.
Learn more on our website or reach out: [email protected]
We combine design thinking and deep technical expertise to partner with orgs to launch innovative products and services and develop the capabilities to deliver them.
The dataset was sourced from ClinicalTrials.gov and processed to filter only interventional studies with industry sponsorship, ensuring the inclusion of trials with a clearly defined therapeutic focus. In the preprocessing stage, text normalization and regex-based extraction were employed specifically on intervention names, rather than titles, to capture radioisotope mentions accurately using a robust synonym mapping. This mapping standardizes various forms of isotope nomenclature, and each isotope is then evaluated based on its established therapeutic or diagnostic classification.
Verification is achieved through a dual approach: a correctness check that randomly samples studies to display key details (e.g., NCT IDs, phases, interventions, and sponsors) for manual review, and a comparison process where aggregated statistics are matched against a pre-defined manual pipeline.
Therapeutic intent is further verified by cross-referencing recognized clinical trial phases, scanning for an extensive list of therapeutic-related keywords in both titles and intervention details, and subsequently flagging studies that fulfill any of these criteria. The pipeline also aggregates statistical summaries (such as the distribution of trial phases, isotope frequency, and sponsor counts), and visualization data is built to stratify the results by phase, company, and clinical application.
Although potential challenges remain, such as deviations in input formatting, ambiguous sponsor identifiers, or limitations in the static keyword and synonym lists the comprehensive verification steps embedded in the pipeline offer a robust mechanism for validating data extraction and categorization.
For access to the raw data, including APIs, please contact [email protected]